Pg/E2 Ratio: compares progesterone to estradiol (E2) to show how well these two key hormones are balanced. In women, a balanced ratio supports healthy ovulation, menstrual cycle regulation, mood stability, and overall hormone balance. In men, it helps maintain healthy testosterone function, mood, bone health, and cardiovascular health. Low ratio (too much estradiol relative to progesterone) can contribute to estrogen dominance symptoms such as fatigue, weight gain, or mood changes. High ratio is less common but may affect hormonal function in both men and women.