A/G Ratio: High A/G ratio: Low globulin production (immune deficiency, leukemia, genetic hypogammaglobulinemia). Occasionally dehydration (relative increase in albumin). Low A/G ratio: Overproduction of globulins (multiple myeloma, autoimmune disease, chronic infections). Reduced albumin (liver disease, nephrotic syndrome, malnutrition, protein-losing enteropathy).