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The following information is for clients of Dr. Skip who have been specifically directed for Progesterone Supplementation and are members of the PMA. See askdrskip.com/disclaimer for more information.

Progesterone Dosing

Progesterone is produced more predominantly during the second 14 days of your menstrual cycle. The cream is usually started on or around Cycle Day 7-10 (CD7-10) around/immediately after ovulation and taken until the onset of menses (a.k.a. CD1). It is produced following the release of an egg by the corpus luteum to maintain the uterine lining until implantation.

It will take approximately 2-4 months of cycling while taking adequate amounts of progesterone to heal your uterus and restore optimal health and fertility to the female reproductive organs.

DIRECTIONS FOR PROGESTERONE CREAM (INFERTILITY):

Use Platt Pro 5% Progesterone Cream ‘or your suppositories’ until the start of your menses on CD 1. Stop when the menstrual bleeding begins on Cycle Day 1 (CD1 is full bleed not just spotting). If you have severe cramping or other PMS-type symptoms after stopping, you may use some progesterone on the first few days of the cycle. Please resume your original dosing protocol approximately 48 hours after you have ovulated & had lots of sex with your partner (as confirmed by the LH surge in your ovulation test from the pharmacy) or become pregnant. When pregnant continue with the recommended dose of progesterone. After it is applied, progesterone only lasts for about 5-6 minutes in the bloodstream because receptor sites so readily pick it up. BE CERTAIN TO TAKE EACH DOSE 5 MIN BEFORE FOOD. The middle dose is crucial.

EACH PUMP DELIVERS 50MG of PROGESTERONE USP.

If using progesterone for 3 weeks without any bleeding (or are NOT having a normal cycle), take a ‘one-week break’ and the restart again. Notify the office if you go more than 3 weeks without bleeding.

APPLY the PROGERSTERONE CREAM onto wrists and inside of your forearms.

If the cream begins over time to take longer to absorb, you may be reaching a receptor site saturation point, which means we may need to modify your dose – please discuss with Dr. Skip before making any abrupt changes.

**Using your forearms negates the need for rotation as that area is highly absorbable due to its vascularity**

If you would like to rotate the cream on your body, other areas to consider for use are the inside of your vaginal wall directly on the labia and/or to the inside of your rectum. Those mucous membranes are utilized for their optimal and maximum absorption capabilities so the hormone creams will be entering the bloodstream immediately after application more like an injection. This also minimizes the processing or metabolizing the body has to do when breaking down a medication via the gastrointestinal tract or liver thus making it easier on the system to utilize thus reducing your symptoms and maximizing your chances for conception. Using different surfaces as irritation occurs and/or to prevent over-accumulation of hormones to the local application site can be helpful. It is totally up to you.

SIGNS OF LOW PROGESTERONE: anxiety, depression, suicidal thoughts, difficulty with concentration, irritability, mood swings, fuzzy thinking, headaches, weight gain, bloating, fluid retention, food cravings, painful joints and muscles, low libido, insomnia, menstrual cramps, heavy bleeding, shorter cycles (less than 28 days) acne, asthma, fibrocystic breasts, painful breasts, ovarian cysts and fibroids.

SIGNS OF EXCESS PROGESTERONE: dizziness and fatigue. They are usually transient after application but could be annoying and worrisome. They should resolve within 30 minutes. Please contact me if they don’t.   If you have trouble sleeping at night, it is recommended that you eat a low-glycemic carbohydrate just before going to bed. In addition, apply the cream again just before eating your bedtime snack. This can be your second, even your third dose of the day depending upon labs and recommendations. SNACKS: Green veggies, brown rice pasta, sweet potatoes, coconut oil and nut butter.

Progesterone Information from Dr. Michael Platt, M.D. at www.plattwellness.com

Progesterone provides benefits to both men and women. The first area is its well-known effect in women as the hormone that helps block the detrimental effects of estrogen. In this regard, it helps prevent menstrual cramps, breast tenderness, and PMS in those women who are menstruating, along with fibroids, endometriosis, PCOS, and fibrocystic disease of the breast. It also eliminates other problems caused by estrogen such as asthma, migraine headaches, and morning sickness. In addition, it helps to prevent all cancers caused by estrogen, such as cancers of the breast, uterus, ovaries, cervix, colon, and the prostate in men.

The second major area of benefit from using progesterone (which is my own personal observation) is the effect it has on normalizing insulin. Insulin is a hormone that is associated with the causation of obesity as well as type II diabetes and its many complications. It is a fact that insulin raises blood pressure and is felt to be a major influence in speeding up the aging process. I suspect that progesterone blocks insulin receptor sites on cells, thereby helping to eliminate drops in blood sugar (hypoglycemia).

As a result, it prevents sleepiness after eating, between 3 and 4 PM, and while driving. This ability to block the effects of insulin also helps with weight loss.   The third major area of benefit of using progesterone is that it appears to block the action and over-production of adrenaline. Adrenaline is popularly known as “the-fight-or-flight” hormone, and excess levels can create anger, road rage, insomnia, restless leg syndrome, and teeth grinding. When anger is internalized, it can lead to depression, anxiety, fibromyalgia, IBS, plus other problems. As a neurotransmitter in the brain, adrenaline can cause the mind to race which can cause problems with focusing – i.e. ADHD, or “brain fog”.

It also causes urinary urgency in adults as well as bed-wetting in children. Adrenaline is probably the number one cause of unexplained weight gain. Leg cramps at night are also caused by adrenaline, and can usually be relieved within 30-60 seconds when progesterone is applied to the area of cramping.

Other benefits: 1) it can have a significant effect on the lowering of blood pressure, 2) it can help infertile women get pregnant, 3) it can prevent or treat postpartum depression, (4) it is extremely beneficial for relieving peripheral neuropathy, (5) helps to prevent miscarriages (6) helps to support the pregnancy after implantation and assists in the development of a very intellectual child and (7) prevents/assists with morning sickness.